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"Fire" - Ohio Players; the main riff is iconic, but the break riff is even better, starting at 1:41
https://www.youtube.com/watch?v=xKAiMTMqJ_Y
"Superstition" and "Higher Ground" - Stevie Wonder. Killer clav work.
"Pass the Peas" - the JB's. Maybe the coolest horn riff of all time:
https://www.youtube.com/watch?v=mUkfiLjooxs
And the horn riff from James Brown's "Make It Funky":
https://www.youtube.com/watch?v=oKJ5sVbIooc
Agreed! What Isley Brothers song did it come from?The horns in "The Grunt" as performed by the JB's (and stolen from the Isley Brothers) should be on this list as well IMO.

The opening bass line on "Radar Love" - Golden Earring
And
The opening riff for "Godzilla" - Blue Oyster Cult
Cities on Flame- BOC
Prison Sex- Tool
I like em simple.
Dissidents by thomas dolby, to me this is just freaking awesome. Look it up peeps
Mississippi Queen
Agreed! What Isley Brothers song did it come from?
P.S. I didn't read the OP carefully enough - sorry about making a list instead of sticking to just one
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I remember noticing back in the day that Blue Oyster Cult had a BUNCH of unusually good riffs holding up some mostly otherwise forgettable songs. After much consideration I nominate for their best: the bass line from ExtraTerrestrial Intelligence
Go look it up. I'll wait here.
See? Isn't that amazing? I still use it as a warm up at jams just to see if I can get someone to jump in. Although, in fairness I no longer remember the lyrics to be able to sing it if they did. Doesn't matter. No one seems to remember the song but me.