At band rehearsal we do everything with IEM and most of my practice at home that way and it's perfect. I have the FT set with the bass dimed, treble 4 o'clock, gain about 1 o'clock cab at 11 o'clock. When I used those settings live it was muddy and extremely boomy. I turned the bass down, messed with the cab sim and couldn't get anything dialed in. I have to mess with it more but thinking the boost without the eq could be more useful for me.
I never go past 9 o’clock on the cab sim if I use it.