There's some chance you'll hear nasty pops from your amp if you unplug the power socket of any pedal, even if the pedal is off, and weirdly enough even if you're signal chain is muted upfront on your signal chain (by a tuner for instance). Either if it's a zap or a pop, not sure it's something great for the amp, would recommend unplugging power-amp before any pedal-chain modification. Guess muting upfront the amp would work as well.