I've done a number of 'chambered' bodies, some of which I've posted here. I've yet to read any clinical research on how it specifically affects the way a bass sounds. I personally have done it for weight reduction and have done so pretty thoroughly using forstner-bits of varying sizes. In all I've done, I have not noticed a negative difference and since each example is unique, it's hard to assess a positive difference as there is nothing to compare to. Bottom line is my basses are comfortable to play being light weight, and they consistently sound as good as all the particulars incorporated. (types of woods used, pu's, electronics, bridges and how they are grounded to the body, nut, strings, etc) I'm all for chambering - just am waiting to discover how targeted chambering can effect the way a bass sounds. Having said that, I believe it gives a body a certain level of resonance akin to a hollow-body. Not the same of course - but there.
My most recent chambered body - bottom = mahogany / top = maple -
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Finished - an awesome sounding, ergonomic and light-weight bass
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