"Sacrifice" is perhaps the wrong word to describe it, but I'm going to take the contrary POV and say yes, just like all-tube vs. regular SS with the big iron power transformers, there definitely are differences with the micro technology.
Of course, that doesn't necessarily mean "inferior," but someone who is used to the razor sharp tightness of a big iron SS or hybrid will often think of micros as not being as tight, and someone used to tube amps will think of micros as missing the great dynamic response and the 3-dimensionality of an all-tube amp. But the funny thing is that a lot of us who prefer tube amps give a thumbs up to micros for their ability to sound somewhat like a tube amp running clean but slightly pushed into the red. I have two micros my own self and I really dig them, though not as much as my tube amps.
But when I hear people saying that there's absolutely no difference in the sound of power amp topology and that it's all in the preamp, I have to laugh. I was around in the days when big iron SS started to get better, and I heard a whole lot of people tell me the same thing about big iron SS power amps vs. tube...there's no difference. HAH! To this day I've yet to play a big iron SS or hybrid amp that sounds like a tube amp and vice versa. Same with the micros.
And I've had many a conversation with soundmen who view the class D technology in pro-level power amps the same way I do...much lighter and making a lot more sense than having a 500 lb rack with a bunch of heavy power amps, but not having the tightness of sound of the big iron.
Again, it's not a question of better or worse, really...just a question of being different. And they certainly are different, just like all-tube and trad SS. Some will favor all-tube as I do, some will favor big iron SS, some will favor micro. But they're definitely different, and it ain't the preamp.