We've been down this road sooo many times.
In my experience, the Crest Audio CA-9 is a far better power amp for bass than a QSC PLX. (I owned a PLX.) For the mids and highs in a PA system, I would not hesitate to use the QSC PLX.
I agree 100%
Case in point: I was using a PLX2402 when I received my pre-production model Read Custom Purity preamp. I instantly had problems getting enough volume without my 2402 clipping like crazy. I called Jack Read about what was happening. We talked about my setup and he felt my QSC amp required more input voltage from my preamp. I shipped my Purity back to him to have it's output voltage adjusted. When I got my Purity back, Jack had even went the extra mile and installed a variable output knob on it's back panel, just in case I ever bought a different power amp with a lower input voltage requirement. I still had the clipping/lack of headroom problems, especially on my lowest notes, but running the preamp's output voltage knob wide open increased my overall volume a bit, yet my PLX still clipped, mainly when I played my lowest notes.
Wanting better low end reponse from my Roscoe's B-string I researched a few different brands of speaker cabinets here on TB. I eventually bought a Bergantino HT210 and a Bergantino HT115. I called Jim a few times and during one of our conversations I mentioned my preamp/power amp setup and the problems I was experiencing. He recommended a few different "lead sled" power amps, I decided to give a Crest CA9 a try.
I know nothing about matching gains, and very little about electronics. I also respect Bob Lee. He's always been very nice when I participate in these threads. So Bob, without beating me up

, please explain why my CA9 was the "better" of the two amps, or how I was running my PLX2402 incorrectly after reading this:
IME when comparing the overall volume of my PLX2402 and my CA9, with the front panel outputs of both amps all the way up, my CA9 was much, much louder. The CA9 also had no clipping problems, even when I played my lowest notes
hard. When I bought my Demeter HBP-1 preamp I tried the same "tests". Once again, the Crest was clearly the "better" of the two amps in regards to low end headroom and overall volume without clipping.
I switched to the CA9 and I kept my PLX2402 as a spare. Later, my band required subs for a gig. We used my PLX2402 that night to power our subs, but it was practically clipping the entire first set. My old drummer owned and ran our P.A.. None of his P.A. gear is low or mid-priced stuff. He has worked as a repairman in the audio field for close to 30 years and I consider him to be very knowledgeable about electronics and sound reinforcement. He was concerned about the PLX clipping, so during our first break we switched my CA9 over to power the subs and the PLX2402 to run my bass cabinets. The CA9 didn't clip once during the night. After the gig, my drummer commented on how well the CA9 did. And as a matter of fact, my CA9 was used to power our subs a few more times after that without a hitch.
I've since sold my PLX2402. I preferred some of it's features over my CA9, like speakon outputs, etc., and it's light weight, but it didn't do what I needed it to do nearly as well as my Crest does. BTW, I didn't notice any tonal differences between my QSC or my Crest. The differences I noticed were overall volume and clipping.
Just my 2 cents.
-Art