I find Chromes to be very slick and smooth, unless my hands start sweating. Then they become draggy, sticky, gummy (whatever you want to call it). But this happens to a certain extent with my roundwound-strung basses as well. The cure is to wash my hands between sets and wipe the strings down between sets.
If I have sweaty hands at at a gig, even with the wiping, my rounds will likely "die" and I will need to removed them and soak them in alcohol or replace them. Nice thing with the Chromes is that they don't need much more than just wiping (or wiping with alcohol). They don't "die" like rounds do. They're sort of... immortal.
The Chromes don't work for everything I play, but I find they work for more than I would have thought before putting them on a bass that really seems to be a good match. In the past, I haven't had that, so I've always disliked flats, in general. Actually, I still don't like flats, in general. But Chromes seem to not be your typical flatwound string. They actually have some upper mid brilliance in them that makes them sound more alive, defined, and biting than other flats. Definitely brighter. They sort of make up for their lack of treble "sparkle" with that pronounced upper mid thing they have going. It can sort of give the impression in the band mix of a roundwound string (kind of), even though the rest of their EQ curve is certainly in flatwound territory.
I was practicing with the Chromes (on a bass, of course!

) last night through a SansAmp and headphones (along with MP3s of songs we do in the band). Good lord! Talking about a mind-bending tone. I don't play with a pick very often because it has always sounded way too harsh for my taste. I just tried it on a whim because my right hand fingers were getting tired. Wow. I've never heard a pick sound so good on bass to my ears (meaning when I'm playing it). It was still sort of "in your face," but in a really, really good, crunchy way. Gotta talk my band into doing a song that calls for a pick tone. And to top that off, I was getting a perfect slap sound out of the Chromes as well for the song "Brickhouse." Old school flat-ish sound, but with enough bite on the slaps/pops to make it sound good. Sounded a lot like the tone in the original. Kinda makes me wonder what the bass and strings were on the original track by the Commodores.
The only other flatwound string that I'm really digging right now is the EB Slinky (cobalt) Flats. Those sound great in a different way than the Chromes. Both really good strings.