I regret mine, and these days I consider myself lucky that I didn't allow it to turn me off from 5s for good. Five years ago, I bought a Peavey Fury V that I hated because the string spacing felt tight and the B only got in my way, so I sold it. A couple years later, I joined a band that covered a lot of modern rock songs that used the low D and C, so I tuned one of my 4s BEAD. Fortunately, this happened during the summer and since I have a job where working in the summertime is optional, I had plenty of time to get used to it.
A year later, I decided I was ready to take the 5 plunge and bought an Ibanez GSR205. I liked the neck so much that over the next few years I purchased several more 5s with a similar neck profile. I now play 5s mostly, though I still have a few 4s equipped with Hipshot detuners.
Three months ago, I bought a 6 and am starting to get comfortable with it. For me, learning to like extended range basses was mostly a matter of forcing myself out of my comfort zone. I think it has made me a better bassist.