At first I started using the High-C setup on my 5-string because at the time I was using a p.o.s. Ibanez amp that made the low B sound like an old man struggling to relive himself with a mega phone held up to him to amplify the experience.
Since, then I've acquired an Eden Setup so this is no longer the case, but when I tried to switch back I missed the personality that the extended upper range gave my bass playing. Once I started entering the jazz realm this was particularly useful for my solo voice, chords, and harmonic (used sparingly, of course)
I find Elixer Nano-web's to be the best strings so far, they even have coated C-strings that retain that brilliant new string sound for at least 4 3-hour gigs. A four-fold improvement from the ernie-ball strings I used to use. My cursed "acid-hands" would totaly deaden my strings after 2 hours of straight live music.