I used to have a mixed driver rig, Ampeg SVT-3Pro with Ampeg 4x10 over 1x15. I didn't have any problems with it. Currently I am using the Rumble 500w combo (which has 2x10" speakers) and the 210 rumble cab, so I have the vertical 4x10, basically.
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It's light weight, very portable, and loud. So very loud. When it's on the Auralex platform, it's about the same height as your setup, but only about 65 lbs total. The setup as you see it here is in my bedroom, which is upstairs, so when I go to rehearsal I need to bring it downstairs, and I have no problems with that. You can't beat the light weight, and I love the tone.
As far as 210 vs 410, I haven't A/B'd the difference in cabs. I would guess the tone would be similar, but the best thing to do is try both, if possible.