The main band I play bass for is tuned low so I use the low string all the time. My main recording project is usually tuned low so I use it all the time for that too. Every band I've played bass in that tuned up to E standard... I still used it all the time. I got a six string to make my life easier with the high parts, and I love it, but if I had to go back to five or four, the low string would be the last to go.