My understanding of the bassbone series is that they are designed to plug into the front instrument input of your bass amp. They are not designed to drive a power amp, the gain is not that high, designed so you will not overdrive the amp. All of the pics in the radial literature show them going into the front instrument input. You are not going to hurt anything by going fx return or power amp in but that is not the intended design for the bassbones.
I use caution on my bassbone od to make sure I am not over eq'ing and tend to use the bassbone eq more and my ToneHammer500 very little. I start with all eq at noon, try the HPF to see if I want to use that and then adjust my bassbone eq and then a small tweak on TH if needed. Seems to work well.