I've not noticed a difference. Some strings, it doesn't have extra downforce on the saddle. Quite the opposite as it' trades downforce for side. If you look at a sideview, you'll see a slight arc over the saddle because the string cannot bend sharply that a thru-body needs.
As to why so many luthiers design their thru-body holes perpendicular to the face of the body, rather than at an angle is beyond me.
I didn't string my Cobalts through the body due to the postings about them being easily broken.