I found that I liked the drives enough in the HX One, that I no longer needed my Aftershock, although my preamp is my primary source of dirt. The Prize Drive is my favorite.
That said, for your needs, I’m not sure if the HX One will work for you realistically. There are some combination effects (modulated reverbs, octave fuzz), but if you use a lot of simultaneous effects, I think a single HX One would come up short.
I have an SA Spectrum at the front of my chain and a Two Notes Le Bass at the end, which gives me some options to distribute some effect duties between the three.
Maybe in combination with something like a Plethora X1. I picked up a little Valeton GP-5 to play around with in a similar sort of setup, although I haven’t actually found a need to use it that way.