This is an interesting point that make the gears turn in my head. Darkglass recently released an amp (900W Class D) that has two of their fuzz effects pedal circuits built in with toggle buttons to bypass both. So, you can either run the straight clean circuit, or add in the B3K and/or Vintage Microtubes effects as needed. It would be uber-cool if an amp like the Subway D-800 had the Walkabout tube pre installed with a bypass option. That would honestly be the only amp I'd ever need.
Of course, what I don't know about electronics could fill a warehouse, so I probably sound like a 5-year-old that wants a flying car.