I've had the most luck with the DarkGlass drives when I'm running them into the Ampeg SVT amp model and cab simulation. Otherwise, you have to do a bit of work taming the top end sizzle that otherwise happens somewhat naturally when running into an amp/cabinet.
I run the Mark Bass amp sim after the DG, and tame the fizz that way. Let’s me dial in just the right amount of grit!
Thanks for the tips. On the instrument side are you both using active pickups?