New York Jets at Indianapolis - Indianapolis. New York is better then last year and Indianapolis is worse. But... It's hard to bet against Payton Manning at home and Mark Sanchez hasn't convinced me that he's that good yet.
Baltimore at Kansas City - Baltimore. Baltimore is just too solid to lose this one.
Green Bay at Philadelphia - Philadelphia. Mostly because of their offensive weapons and they're at home. I'm not sure on Green Bay's health as I know they were really beat up earlier this year. This really is just a guess for me. I'm really anxious to see this one.
New Orleans at Seattle - Seattle 
We were blown out earlier in the year at New Orleans but... Matt Hassleback threw for more yards against the Saints then any other quarterback this season, and take back a couple of Marshawn Lynch fumbles, maybe things would have been a little closer. Not to mention our best corner was replaced by a rookie after leaving the game with a concussion, and Chris Ivory was not on anyone's Radar at the time.
Reggie Bush hasn't been the same since his injury, Pierre Thomas hasn't played at all really and Chris Ivory (Who really caught us by surprise) is on IR. Julius Jones? Ask any Seattle fan how he did up here...
Which leaves Brees. Arguably the best "weapon" in the league. But... He's playing in a Stadium that is difficult to play in, and in weather that is far from perfect. Once Seattle stops a now non-existent run game we can go to our 7 DB packages and let him throw. He's been throwing more interceptions this year and it's going to be cold, loud, and wet on Saturday which gives us a better chance then in the dome.
Then there is this...
Frankly, I'm looking at this as a bye week for the Saints, with a bit of R&R in the beautiful NW US.
My guess is New Orleans is thinking it too as they had at least twice this year. Once against Cleveland, and once against Arizona where they lost both times.
Finally, New Orleans is playing against a team that won a lottery ticket to play and has nothing to lose in a stadium filled with people who have seen their team getting crushed for the last few years. It will be raucous.
And when Seattle wins, eh... That's pretty much all I've got try and convince myself Seattle has a chance here...