Here's my thinking - in the past three years I've used either two smaller cabinets (in my case a 210 and a 112) or one 410. I see advantages to both. I started out with the 210/112 and still have those at our rehearsal studio. I bought a 410 in order to have to schlep only one cabinet to the gigs.
While it is nice to have the one cabinet, it's still a 60 pound cabinet and not exactly something I can sling over my back. Casters help, but I also like the added height that I get with two separate cabs, and I usually stack them on the thin end to take the maximum advantage of that height. To get the 410 off the floor I use a stand, which a)is one more thing to carry to a gig, and b)completely uncouples the cab from the floor, for better or for worse.
All of these cabs I have mentioned are Avatars. I've been thinking it may be time for me to step up to something better, so I am wondering about moving to the Epi 410 that is ever popular around here, or two Epi 112s, which weigh a paltry 30 pounds each. (My Avatar 112 is similarly light, but the 210 weighs somewhat more).
At the same time, I'm intrigued by the three way cabinets out there. I've played through an Accugroove Whappo Jr. and liked it. I am curious about the three-way Dr. Bass products, although I am leary that Dr. Bass would be another Avatar-type choice (outstanding value, but an undeniable tonal compromise) which is not the choice I am trying to make. The Avatars are really not that bad at all - if I go to the trouble and expense of upgrading I want to absolutely be an upgrade.
So, as you can all see, I'm just a mess of GAS, more or less.