I have tried going parallel and I absolutely love it. Distorsions are amazing in parallel. The chorus has more low end, being more noticeable in higher frequencies.
I keep the octaver in parallel because sometimes I only use the octave, not the real note, so having it in parallel wouldn't be that effective for me.
Tuner-->Comp-->Octaver--Boss LS-2-->HPF/LPF-->Tone Hammer
Loop A Fuzz-->Overdrive-->Line6 M5 (most of the time, a Chorus)
Loop B: Clean
I keep the octaver in parallel because sometimes I only use the octave, not the real note, so having it in parallel wouldn't be that effective for me.
Tuner-->Comp-->Octaver--Boss LS-2-->HPF/LPF-->Tone Hammer
Loop A Fuzz-->Overdrive-->Line6 M5 (most of the time, a Chorus)
Loop B: Clean