I just got the PX-101 in the mail yesterday but haven't had time to play with it much. I'm also using passive basses with flats, so I'll be going back to your post to follow your best practices!
My best practices seem to vary each day!
Gain structure is one of the most important with this one since there is a lot of interactivity between knobs.
I've used lots of fuzzes and octavers in the past but have settled on a good rotation lately:
Fuzzes:
Zvex Mastotron -- agreed, it's great for this use case.

Broughton Maestro -- I had a Malekko B:Assmaster but let it go due to size when this one is at least as good to my ears.
I liked the Maestro once I figured it out. Unfortunately that was after I sold it
The Hiero BEAD serves a similar purpose for me now. It gates a bit better but doesn't sound as open as the Maestro
Crowther Prunes & Custard -
I'm curious about this one and how it compares to the Mastotron. Do you use it in an octave/filter/fuzz chain?
MXR Sub Machine -- I'll never stop talking about how great this pedal is. Fuzz, sub octave series or parallel, and octave up footswitch.
This is new to me so I will have some videos to watch.
Octavers:
3Leaf Octabvre Mini -
Sold my Octabvre III. Maybe didn't give it a fair shake but the letters were falling off anyhow so it had to go.
Broughton Subsonic -
From the newest batch or prior ones? Some say the newest batch has more OC-2 flavor.
MXR VBO -
this one gets a lot of love, do you have a preference vs. the Subsonic?
+the Sub Machine in a two-in-one solution.
The Mutron Octavider+ is really good for an two-in-one solution too, but the octave flavor is different than the OC-2 one, and the overall output is controlled by the fuzz volume and that's not great for my needs.
I can see that causing issues since gains are so important when filtering comes into play.
I'll be posting a pic today to the compact thread where a few of these will make an appearance.