I'm leaning towards the pair of HD210s as it seems like the more sensible option, and I really dug the sound of that cab when I tried it in the store.
That's probably the right way for you to lean. The NVxxxT cabs have tweeters to cover the high ground (so to speak), but are more about low mids than low end extension. The big NVs are a specialty item: I only recommend them to those looking for vintage punch, or "tight" stage tone that doesn't muck up the onstage and/or FOH mixes with low frequencies. Fact is, many prefer cabs that deliver the lows, and don't mind taming those lows when necessary (EQ, HPF, whatever).
Four tens won't move as much air as six tens or four twelves, but my rock band plays loud and my 2xHS210 stack hangs well enough. There haven't been many occasions where I've actually noticed speaker distortion.
Tone and volume aside: the 2xHD210 stack is modular, and just as easily portable as the tilt-and-roll NVs if you get a folding hand truck (I did). If you have to deal with stairs at any of your gigs, I suspect you'll be grateful to carry one 2x10 at a time rather than one big 100lb box! 2x10 cabs stacked vertically have a smaller footprint -- helpful on a cramped stage. The vertical stack is taller and therefore more audible than a 4x10 cab/horizonally stacked 2x10s -- helpful when you have to stand close to your rig.
I still trot out the NV610 with the rock band because I love the midrange punch. I play low-B five string, but the low notes are still fun: that is, not a lot of
fundamental, but plenty of 2nd harmonic. Also, the lack of tweeter keeps the high end smooth when I dial in overdrive (of course turning down a tweeter will do the same). That said, I'm using the 2x2x10 rig more often because I don't always feel like dragging the big box in and out of my wagon. I also go with one or two Berg CN112 cabs (neo) whenever possible. I give the tonal edge to the HS210s, but it isn't always worth the extra weight.
Oh... none of the above is specific to the Studio 1200, it'll sound great through any of those.