It can be dangerous to use 1/4" plugs with some class D amplifiers (not Peavey) that have bridged outputs because the negative side is not ground, it is a DC voltage that can be upwards of 50V, so if you touch the metal case of the 1/4" plug and the chassis at the same time, you get shocked. Since class D is becoming more popular, expect to see more Speakons.
+1, and many thanks to you and agedhorse for patiently educating us on these matters.
This is an extremely important point. We are accustomed to associating "bridge mode" with PA power amps, but many Class-D mono bass amps operate in bridge mode with non-ground-referenced outputs. This includes many of the new "micro" bass heads. You can no longer assume that the outer shell of a 1/4" speaker connector is at a safe ground potential. The connector shell could touch another piece of gear and cause a short circuit.