Kevin, all the posts above are great.
I am just a local part-timer as outlined in my profile. But I've been gettin' paid to play bass since 1979, FWIW. My 2 cents, looking at your OP:
1) I much prefer using a high pass filter instead of a bass EQ knob to control boominess w/ piezo pickups on DB. The HPF-Pre is probably the latest and most affordable example of an outboard unit that does just that.
You will never go wrong doing this IMHO, Bolo is right on the money. Sometimes the Bass EQ knob won't completely cut the frequency since it's not actually designed to do that. It depends on the amp and how it's preamp is voiced.
2) As a generalization, clacky or honky mids live somewhere in like the 700-800 Hz region. I don't know if your GK allows you to cut those or not, or how big or small the Q is. Anything labelled "Contour" is usually a mid-cut, but more often than not voiced moreso for slap EB. And be careful w/ it for DB. The magic for DB is in those mids. I didn't come up with that, but find it to be true in gigging situations.
Although I can't tell you the specific frequency range, the midrange EQ on the MBE voicing favors the Electric Bass and once agian you can't totally eliminate it's effect. It's still there when the midrange is completly dialed out.
3) I always thought the Underwood and the GK matched up well from what I've heard in terms of input impedance. But maybe a preamp with a 10 Mohm impedance would help and sound a little less brittle. HPF-Pre again. Might be worth a shot.
I had a long chat with Don Underwood once and he commented on the fact the Walter Woods set the input impediance on his amps at 1 megohm to match the Don's pickup. Rick Jones also set the input impediance of all the new AI amps at 1 megohm because in his words the only pickup that actually needs 10 megohm is the Fishman BP 100. GK's have a 1 megohm impedance.
String choice and speaker placement (especially how close or distant you are from walls and corners, speaker on the floor vs. raised) are also in play. In fact, that's really all I tend to focus on from one room to the next. I just run the EQ flat. (What??

) But I've spent a long time getting my pickup fitted (not to mention trying different pickups) and getting my mic positioned the way I like it in order to make what I (and others) consider to be a good sound.
As Bolo says sometimes flat is best, because if you can't get a good sound from the Bass, PU with a flat setting you most likely won't be able to "dial" one in.
Ric