Nope, not unless I'm playing an acoustic electric bass and that's only because the piezo pickups in those require a bit of massaging to sound the way I like them to sound. The Sans Amp VT21 is my pedal/preamp of choice if I have to use one. But if I'm playing my Bird it plugs directly into the GK Combo, which has all the sound shaping options I need.
For me, the whole idea around the ultralight combo was to keep things as light and compact as possible yet still have decent sound. I went down this path when I blew my right shoulder out and couldn't lift anything with that arm. I also switched to short scale basses (Gibson SG, Squier Jaguar, Squier Bronco and Kala Uke basses to lighten the load). The GK 210 combo does sounds good for the size rig that it is, it punches well above its size. The GK 212 combo even more so, but it also weighs more and starts to creep into my medium size venue rig territory. If I didn't have any other rigs I'd be looking at the GK212 more than the 210 as long as the 10 additional pounds and cost aren't a factor.