If I may jump in (as if this weren't generally a free-for-all)...
I ran my Hagstrom this way for a while. You can actually get good use from it with a two channel amp if both channels run simultaneously. I also ran it through two amp/speaker setups, but that took up too much space in our little apartment, and wasn't worth the effort given my lack of expertise (and budget) at the time. It was a fun experiment, and would be more so with the right effects (see budget comment).
To use it to its *full* advantage, you'd probably be in the studio or a smaller venue, but you can still get a good bit out of it anywhere. I mean, if you're playing stadium gigs, you probably have the bucks to buy what you want.