Not sure how well real world settings will translate into the virtual universe, but I'd be happy to share. With my Bicentennial running into a '71 V4B and flatback SVT bottom, my rehearsal settings were always pretty much as follows: volume at 10 o'clock or so, Ultra Hi on, Ultra Lo off, bass at 11 o'clock, mids at 10 o'clock (with the midrange freq selector in the center position) and treble at 10-11 o'clock. I found that by rolling the tone controls back from the center (flat) position, I could run the volume knob up higher to get more grit. Naturally, if the virtual amp has a master volume, that might not be necessary. I also found that turning the Ultra Hi on, instead of turning up the treble yielded a slightly different sound.
Having said all that, old Ampegs usually don't require too much tweaking. The mojo is in the midrange control and mid frequency switch. My advice would be to set everything flat (Ultra switches off) and go from there. Bear in mind also that different eras and varieties of Thunderbird don't all necessarily carry the same sound characteristics - the Bicentennial is a way different than my Gibson Thunderbird Studio, which is sorta similar to my Epi Classic IV Pro and none of them sound like my Epi CS/LE T-Bird IV. 60s birds are different, also.
BTW, a B15-R is essentially a 90s V4BH, which doesn't exactly sound like either a vintage V4B or B15N.
Have fun!