Amp designers wouldn't put EQ controls on their amps if they didn't expect you to use them. I try to buy amps that meet my tone goals when set flat because I don't want to have to be tweaking knobs all the time to find a sound I like. Chances are with most amps if you're cranking knobs heavily, your tone in going to suffer whether you think so or not. For me, EQ is there to adjust to the venue. If it's too boomy, I work with the bass control. Too bright, a small tweak on the treble. I occasionally will adjust the bass to maybe 1 o'clock if I'm outdoors. I like to put a little extra high mid into the mix for note definition if the room is boomy. Right now, I have six amps by four builders: GK, Glockenklang, Mesa and Eden, and they all sound good set flat.