Well....sorta. I have 5 patches. All of them are the same preamp (Sansamp), same settings (flat amp sim, same levels on the Sansamp), same D-comp compressor and 5 different amp sims. It's still a simple setup, but when I change between patches I get different tone colors (sometimes very contrasting like Hartke vs SVT) but with the same basic preamp levels. Along the same line, I've tried just running the Sansmp and compressor and using my physical amp's characteristic tone shine through. I was very pleased with the results.
Overall, switching to the Sansamp tonight was a major "AHA!" moment for me. My BG250-210 has a new depth and resonance.
EDIT:
Well I guess the correct answer is...No.