Hipshot makes quality products - no doubt. And their detuners work, There are a couple of caveats though.
One is that your neck may flex as you activate the detuner. That will affect the tuning of the other strings. But with a good stiff neck this may not be an issue. The problem is exacerbated the further you drop tune. A semitone may not cause a significant detuning of the other strings but a full tone might. Drop from E to C and it may become more problematic.
The second is that the string may hang up a bit in the nut as the tuner is activated. So your string may be a bit sharp when you drop down, but it may even out as you play. And it may be a bit flat when you step up, but it too may even out as you play. In such a case, if you set the adjuster so that the string is in tune when you drop, it will gradually get flat as you play. And similarly when you step up it will be in tune at first but will gradually get sharp. To avoid this you need to make sure that the string slips easily in the nut slot and doesn't bind up. That is easier to accomplish with quality bone or most synthetic bone nuts. Brass nuts can be a bit grabby as are many plastics.