For at home, 18":
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Why? Because moar is MOAR.
For my weekly semi-acoustic jams, 10":
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Why? Because nothing exceeds like excess. Way, way more than I ever need, but it's all of 26 lbs. and the cab part just kind of dropped in my lap, so all good.
Gigging, when I still did, 12":
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Why? Because my 115 or 215 rigs only made it out of the house for a tiny handful of gigs over the last ten years I was playing out, and the 112 easily sounded as good or better for anything I ever did that actually paid. If I needed more than a 112 someone else would've been welcome to that gig anyway, in all honesty.