Sure. Filters and fuzzes generally both like to be first.I find that mine can be pretty noisy depending on where it is in the signal chain. I agree, the clean blend is great, but I'm gonna try it in the Broughton Filter FX Loop later today, since that usually improves most fuzzes.
I have been in love with a filter fuzz from WestCo that splits the input so both sides process a clean signal. But the fx loop would basically do the same thing.