IMHO (as usual)...
First, SC all the way, no doubt, no question, no hesitation... unless you just have some horrid venues that you play and you can't live with the fully blended tone there.
On the placement, not long ago, I'd have gone for the 70's placement myself, as I really dig aggression... however... lately I've learned to appreciate having a slightly fatter sounding bridge pickup. You only lose just a touch of the edge in the slap tone, but IMHO what you gain is a fuller sweeter tone with still plenty of grind and growl, and a more "useful" bridge pickup solo tone with less EQ. That said, I know the 70's position would also sound great if that really calls to you... to be very honest, I'd think it wouldn't be a night/day thing anyway, and if that little bit of extra edge is what you're looking for, that's a good way to get it.
My MV5 is as generic as they come... standard pickup position (SC's), no figured woods or hardware options. Blows me away every time I play it. Kills in a live mix and records extremely well. It just needs nothing tonally. Nothing.