My experience with the ECB81 set (45-65-80-100) is rather limited. I found them quite unbalanced in tension (ie G&D way tighter than A&E) so ended up switching to the ECB84 (40-60-80-100) before I had a chance to break them in thoroughly.
That said, my ECB84 took a couple of months for the initial break-in. By the time I took them off 4 yrs later, the 100E had gone all thuddy and lost a lot of the definition.
I prefer the higher tension on D and G, being smaller strings the higher tension seems to make them play easier for me. But having said that I've tried and liked most Chromes sets. They're one of my favorite strings for flats.