I may have missed this but, what cabinet are you going to be using?Thanks for the reminder. I did 10 years of The Nerve, in just about every venue imaginable lest arenas (and MSG), and never used anything outside of my Peavey TKO, which I'm pretty sure was only 150 watts. I think that memory settled this for me.
For me, it's really about what I need behind me, as most small coffee shops, small dinner things, and venues I can get by with a 1x12 cab, even though my head (WD-800) can put out 800 watts, I run it at 300 watts. Anything bigger, there's usually PA support with some sort of monitor system and again, I only need to worry about my own sound comforts and the Mesa head and 1x12 are enough.
If your cabinet can hang and you've got the scrilla, go for more just because, if not, that'll do