If the band is going to play it in Eb, I play in Eb. Not too terribly different than D as I rarely play open D or open G for tonal reasons.
If the band is going to play the Eb song in E (like so many seem to do for Superstition, for example), I use software to transpose the song up to E.
If the band is going to play the Eb song in E (like so many seem to do for Superstition, for example), I use software to transpose the song up to E.