I went through all the stages of grief with this idea a while back. I've got some great preamps and love the idea of just bringing a preamp, simple amplifier, and a cab that meets my specific needs to a gig.
Here are the things I learned on my journey (just my personal feelings):
1. The more I played with non-commercial power amps (boutique/whatever you want to call them), the more I appreciate all the hoops and certifications mainstream manufacturers go through for the sake of consistency. I have one left that I keep as backup now, but I don't gig it as a main power amp anymore.
2. Good quality combos are actually more useful to me than I used to give them credit (I'm looking at you Acoustic Image TEN2). Mainly for the times I don't want to carry a bunch of stuff to a gig due to space, distance, whatever... I can plug my preamp into it, tweak the levels a little, and be good to go without lots of extra equipment. But I still don't care for lower quality combos because they sound terrible and I low-key hate them.
3. For my use case, I would rather have a nice powered cabs that meet my needs as a bass player for medium sized gigs, anything larger is going FOH anyway. I love my powered MAS 16 cab for wallpaper gigs (see previous comment concerning boutique amps), but if Mesa or Bergantino released a powered cab that met the needs of moderately loud gigs, that I could just plug my preamps into and go... I would absolutely be selling off some of my gear to get one. I know JBL, QSC, EV, whatever have that market sort of locked up, but I'd rather put my money towards the Mesa or Bergantino product.
TLDR- In case anyone is asking, tell
@agedhorse or Jim Bergantino I'm a size 112 or 210 powered cab. KTHXBYE