They are both fantastic amps and do very different tubey flavors. I've loved both, but ditched the 400+ years ago and still have a Walkabout that I never intend to let go of. At one point I had a 400+, D-180, Carbine and Walkabout together and tested all sorts of mix/match preamp into power-amp combos between them. I actually found the Walkabout preamp to sound pretty bland through the other power-amps, and its magic really seemed come from that driver tube which came after the FX loop (any preamp into the Walkabout power amp sounded really good!).
As mentioned, the 400+ tends to be tighter and punchier by nature. The 400 pre would get lots of crap on here for the "cut-only" passive Mid, but with the pull-knob mid-boosts and graphic-EQ I found mine to be a very mid-heavy amp that could crunch and articulate where the Walkabout tended to compress and smooth-out. The 400+ could get MUCH louder with less apparent compression. The 400+ could also have much more top-end and higher-mids on tap. That said, the 400+ was probably the least intuitive amp to dial in that I've ever owned, whereas the Walkabout is one of the easiest (it just always sounds good!). Once I learned the 400+ I found it capable of a range of punchy and aggressive tones I've never found in another amp since (though my Prodigy gets in the ballpark and does some stuff the 400+ couldn't do in a much smaller/lighter package).