I think it will be great, better food than New England for sure!!! The level of musicianship in the Boston area is so high, though. I will really miss that. I don't think I've had a bad gig, I am lucky to have had a situation that has allowed to be prepared for these shows! Proximity to NY has been great as well. I am not afraid of snow, so I've enjoyed the weather.
The day to day life can be a real drag - the roads and trains are not laid out well, anything even mildly interesting is an hour there and an hour back minimum - and too often it is just mildly interesting. Not a single bookstore I'd call great, a few good ones, same with record stores.
The Boston museums are pretty backwards and have wack priorities (colonial furniture at the MFA, "virtue signifying" at the ICA), the colleges, Harvard, Brandies and Yale in particular have strong museums.
The food can be good and even great but, it terrible and expensive often enough that taking chances is not advisable!
In the other places I lived, Oakland and Houston, I was able to be closer to the centers, it seems like I'll be able to do that in St. Louis, which will be nice. The art institutions also have far a more serious attitude about modern and contemporary art, so I will enjoy that.