IME a gap between the neck heel and base of the pocket route, like we see in OP’s photo results from the through body holes being an RCH too small, allowing your neck screw threads to gain purchase in the body. When that happens the screw is pushing up on the neck as it passes out of the body while trying to pull the neck down as it enters the heel. You will strip your screw head or neck threads if you keep cranking trying to close such a gap.
The solution is to enlarge the through body holes just enough to allow the neck screws to pass without having to thread them through the body. I remove the neck, then flip the body and drop a neck screw in a hole until it can no longer pass without turning it with a driver, then use a screwdriver and a block of wood to tap the screw head down to the neck plate. You will still need to unscrew the fastener, so repeat the process until you can pull the screw out by hand and push it back down flush by hand. Keep in mind removing the screw with the neck in place will raise it enough with a driver to allow a good finger grip on the screw, you want some resistance, but not enough to require a driver for further removal. The trick is knowing when to stop enlarging the holes. You don’t want them loose enough the screw will fall out, but you shouldn’t need a screw driver to remove it once it clears the neck heel.