I should add that the Two 10 easily handles everything my Mesa 800+ can throw at it, the Four 10 even more so. I really appreciate the character that is built into the 10 speakers, and it seems an especially good fit with the Mesa. Of course YMMV but I have never needed to consider any tone shaping pedal with the 10s, which seems to come up regularly with the 12 series.
I use the D800+ with a pair of Two10, and like you find the match to be extremely good.
I owned a Compact and a pair of BB2 in the past, but as good as they were (they were!) I spent a fair amount of time tweaking knobs, while with the Two10 cabs I seem to get there with minimal effort no matter where I play. A lot of it has to do with the amplifier (I like the combination of adjustable HPF + voicing + bass EQ to shape the low end) but using other amplifiers I have a similarly pleasant experience.
I hesitated about the Two10 as I heard them described as 'dark' and 'old school' and I was also mistakenly thinking that I needed a lot higher frequency response, with the idea that I can always tame the top end if I don't want it but won't be able to put it back if the speakers cannot reproduce it... but they roll off at 6 or 7KHz (can't recall) which is plenty for bass. I don't go for old school vintage type of tones at all, these cabs are much more versatile than what their "Retro" label suggests.
Their 12" series is good, no doubt, but I have a feeling that most people would probably find it easier to use their 10" series. I regularly get compliments about my sound, which I didn't when using the Compact or BB2. I play in several bands, covering ska and reggae, funk, and rock... There is thumping, there is slapping, there is overdriven bass (the Two10 are particularly sweet with overdrives)... strong prominent bass in most cases, with tight bottom end and good definition without overpowering anyone...
I'll shut up. I really love these cabs. They've made my life a lot more comfortable, and in particular in combination with the Mesa D800+
The only thing I don't love is that I bought mine after they had gone through some 'teething' problems, where the glue they used was not strong enough and the tolex was peeling off their first cabs within a few months. It was their first foray into using tolex covering and it was a bit unfortunate... although I have a lot of sympathy for them, given how the company started and Alex' ethos. I bought mine after they sorted this... however, 3 years on, one of my cabs started peeling off at the seams on the back, and the other looks like it may go that way soon. It happened rather suddenly, despite my looking after the cabs and never being subjected to extreme temperature changes or anything. It's nowhere near as bad as the first ones, but it's not 'pretty' either.
HOWEVER... and this is something that still impresses me, when I posted some comments on another forum asking for solutions, Alex saw it, tracked me using the serial number of the cab (visible in the picture I posted) and emailed me to discuss it and offer a solution. That alone was pretty cool, I thought. The only reason I didn't contact Barefaced directly was that I did not want a glue kit. I was under the impression that it would be a messy affair, lots of clean up... and I am not very DIY-minded so it would likely look worse after I attempted anything. I am too far from them to consider taking my cabs to them for a retouch. I was considering simply putting some black duct tape around the seams. It's on the back, so it's not exactly going to be visible. But Alex explained to me how the new glue is water-based and temperature activated and the whole process seems pretty painless even for a DIY-hater like me.
I remained a fan, even with slightly peeling tolex, because I love their products and attitude (and have you looked at their guitar cabs? There's something really cool happening there) but those emails from Alex really cemented my faith in them.