I have a number of 4x10's in the "collective," and I hang onto all of them for a reason. Any one of these could be considered "best" in the right situation, with the right amp/bass, etc. And of course, subjective opinions vary widely:
Bergantino AE410
Bergantino HS410
EA NM-410
Gallien-Krueger Neo410
Glockenklang Take 5 (4x10)
Mesa/Boogie Diesel 4x10 (Deep version)
Mesa/Boogie Traditional Powerhouse PH410
Orange OBC-410
Orange SP410 (neo drivers)
Reeves 4x10 (sealed)
Sadowsky SA410 (two)
Trace Elliot 1048H
With tube amps, the pair of SA410's or else the Reeves typically get the nod, though both Orange cabs like tubes, as well. My favorite overall is probably the Glockenklang, with both Bergs coming in very close. The GK is right up there, and a great bang for the buck. My old Mesa/Boogie Diesel still sounds great, but at 120+ lbs, it's not worth the risk of bodily injury to continue to gig with it (I have hundreds of gigs on that cab, though). The new Traditional PH410 has a very unique voice which works fantastic with some heads, but it's not a universal fit. The Trace is very flexible, and likes both tube and solid state heads, but again, it's a big, heavy beast.
Lots of great choices, IMHO/IMHO.