Over in the home audio world, ported vs sealed is debated, and one of the accepted tenants is that sealed cabs have better midrange because midrange energy escaping through the ports is unwanted coloration.
Years ago (before I got into bass cabs) I was working on optimizing the stuffing inside a sealed box, and was using two identical boxes and doing A/B comparisons of the different stuffing configurations. Anyway at some point I decided to port one of the boxes just to confirm that sealed boxes really do have better midrange. I mounted a 3" diameter flared port on the back of one box. I used only acapella vocals or little-girl-with-guitar recordings to minimize any low-end advantage the ported box might have. As usual my wife did the actual listening, without knowing what was different about the two boxes. I told her to focus on the voices and pick which sounded most realistic. So it was a controlled blind test with a very small sample size.
Well to my surprise and dismay, she preferred the ported box! That went against all of my beliefs on the subject, and against the collective wisdom of vast herds of audiophiles. I kept tweaking the damping material in the sealed boxes, and even took out all the damping material in the ported box to handicap it as much as possible, and every time she picked the ported box. And I agreed with her.
In retrospect, I think I just happened to stumble upon a ported configuration that worked really well in the midrange, with the rear-mounted flared port.
Anyway, point being, in my somewhat unorthodox opinion, ported boxes can offer minor advantages in the midrange region.
As far as combining ported wooferboxes with sealed mid-chambers, or vice-versa, I see no reason not to mix and match as long as the midrange drivers are adequately protected. My marketing department likes to go on about my "open format" mid-chambers, but in a way they're really just high-tuned ported boxes (and have to be approached as such from a crossover standpoint).