I wager the cause of your issue as described is either the result of an out-of-phase condition or bad contact (likely in the combo Speakon jacks of the One10s when employed for 1/4" duty.)
I highly-recommend use of Speakon cables over the 1/4" options on both the BB800 and your two One10s, despite the existence of this option on the equipment. As the BB800 only has one Speakon out, you then would have no choice but to daisy chain, but this would no doubt be the better connector choice.
Also in the name of safety and best practice, I suggest relocation of your Pedaltrain board to the floor
Cheers!