IMHO, it is an adequate replacement.
What I loved about my 750 was that it sounded like a "matured" SVT on steroids. Very thicks low mids that have punch and oomph, a low end that is wide but controlled, and a high end that is crisp without being harsh.
The Mesa D800 captures this same tonal footprint and idea in a much lighter package. The low mids punch, the lows are wide but focused, and the highs are crisp and not harsh. But what is also surprising about the Subway is that it's a very 3D sounding head. The notes have a liveliness to them that I haven't experienced in another micro amp. It actually captures the spirit of an amp like the 750.
That said, I still consider the 750 in a class of its own. It is, IMO, the best bass head ever made due to its simplicity, ruggedness, and balls with its tone. But, I immediately put the D800 after it. The weight savings coupled with a very similar tonal footprint to the 750 make it a strong replacement. The 751 actually comes third for me due to the change in its mids.
Ultimately, both my 750 and 751 got cut due to weight, size, and me not gigging enough to justify having them.
A used D800 can be found for around $550 IIRC. It's definitely worth trying out. I haven't tried the DI yet, but I've heard good things. If it sounds anything like the it does when you use it as a headphone amp then it is very good.