That's a tough one. On the positive side, four bands of semi-parametric EQ is very powerful. On the negative side, the Q's are quite wide on the midrange, so you don't have the ability to 'notch cut' to control wolf tones or feedback in very specific frequencies with DB. Of course, not many amps have this ability anyway.
Also, the presets are wonderful for doubling, since everything (EQ, compression, input gain, post EQ volume, etc.) is storable. So, it is easy to have totally different voicings, input gain, etc. for your slab versus DB at the push of a button. The only downside versus a true multichannel amp is that you still only have one input... so you would need to plug and unplug the basses when switching on the gig.
Regarding piezo honk, the tight, warm voicing of the RH450, along with the relatively high input impedance would make this amp appropriate for piezo pickups (i.e., the amp natural rolls off deep bass and upper treble... the typical problem areas with piezo pickups), although I'd never use a pure, raw piezo signal without some sort of buffering anyway.
For those DBers who like a very articulate midrangey tone (like using the little GK MB150 micro combo), this head would most likely do the trick. It of course sounds awesome with slab, and will do everything short of full Marcus Miller uber sizzle.