Here's my setup for a show at a 200-250 seat venue tonight, I will have FOH. My input gain is on the left at 9:00 or so, much above that and I'm constantly pegging the VU. The "tube" and amount of it is the knob just to the right low side of the VU, the manual suggests somewhere between 9-12, I'm at 10ish. I have the bass backed off a bit in my eq, and the bias is backed down as well. Tbird pickups make lots of bass but that doesn't carry well out the FOH and the stage gets muddy. The middle knob in the low position is compression and I'm finding that I like a little, the right low knob is a Sub Harmonic octaver, for certain songs, it's the bomb!
For tonight, I'll probably push the master out on the far right up a few notches, but that's about it.