You may have to file the string slots in the nut a little wider, in order to get a proper action in the first few fret positions. But I wouldn't do that straight away. First string it with BEAD and see if you can get used to it for about a month or so. If you think you're going to stick with the BEAD, then file the grooves in the top nut to the desired string widths. There is no way back... You're going to have to replace the nut if you're switching back to EADG.
Good point. And none of these basses are what I would consider "standard" TBs and are a tad rare one way or another, so non-reversible gives me pause. Maybe follow whomever made the suggestion to switch the Epi VP as it should be relatively easy to pick up another for gigging purposes down the road.