The Reunion Blues bags are the most bomb-proof cases I've seen, but they have downsides. I've had mine for about ten years, and other than dirt, stains etc. its as good as new, and it has been everywhere. I could not ask for a more protective soft case, or a more durable one.
Problems:
The materials, while super tough, are harsh to haul around, imo. The straps and handles, though they may last forever, eat up my hands and arms in rather short order.
Weight. They weigh a ton.
Size. They don't collapse or fold; the bag off the bass is as big as the bass itself. You can't stuff in under a chair or behind your amp or whatever.
Virtually zero water resistance.
Spendy.