I played 1234 for the first 23 years and started having wrist and arm pain. In 1996 Carol Kaye switched me to 124 and the pain went away. It also served me well when I switched to DB 3 years ago.
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And i will add this, if you have nothing musical to say in your playing then it will make no, difference what technique you employ...with the great players it was never about how they played....it was about what they played.
Fergie,
I would like to totally disagree with you or get some explanations about your dichotomous statement.
For me "HOW" means - articulation of your note, phrase, motif, swing, groove, riff, solo, etc...
"WHAT" means notes - just dead notes that you, as the musician, need to revive.
Now, about fingering.

Really??? You didn't get what he meant? Come on...of course you did.Fergie,
I would like to totally disagree with you or get some explanations about your dichotomous statement.
For me "HOW" means - articulation of your note, phrase, motif, swing, groove, riff, solo, etc...
"WHAT" means notes - just dead notes that you, as the musician, need to revive.
Now, about fingering.
Let's say I need to play F, F#, G# / 1-2-4 frets on the E string.
Are you going to use 124 fingers?
I would.
If I need to play C,D,Eb / 3-5-6 frets (for C minor)on the A string, are you going to use 124 fingers?
I wouldn't.
I would use 1, 3, 4, because it would be very uncomfortable to use 1,2,4 fingering.
What fingers would you use for string crossing:
F/1 fret - on the E string, B/2 fret on A, F/3 fret - D, and B/4 fret - on the G string?
I would use 1,2,3,4.
If I need to play "walking bass" -
D/5 fret - on A, (2 finger)
F#/4 fret, G/5 fret, G#/6 fret, A/7 fret - on D,
I would use 1,2,3,4 fingering.
If I need to play triplets:A,A#,B and A#, B, C on the D string, I would use 1,2,3 and 1,2,3 or when exercising, I would use 1,2,3, and 2,3,4.
If I need to play C, D, Eb on A, and F, F#, G on D,
I would use 1,3,4 and 1,2,3 fingering.
If I need to play triplets: Bb,A,Ab/3,2,1 frets on the G string and F,E,Eb/3,2,1 frets on the D string, I would use 4,2,1 and 4,2,1.
If I need to play the 16th notes
D/5 fret - on A,
G#/6 fret, A/7 fret - on D,
D#/8 fret on G, D/7 fret, Db/6 fret, C/5 fret C#/6 fret on G,
I would use 1,2,3,4,3,2,1,2 fingering.
If I played the 16th notes from "Come with it" - "Rocco" Prestia -
E, E , E, E - on A,
A,A,A#, B - on D,
D, D - on G, and
D,D - on G,
B,B - on D,
I would use 1,1,1,1 for E on A,
1,1,2,3 on D,
1,1, on G, and
1,1 on G,
3,3 on D.
+1 started on guitar first, I have been trying the 124 method since I hear so much about it but I screw up too much trying to use it, I can see the comfort of it though. It was much easier to learn floating thumb, love not having unwanted notes ring out anymore.
