Since I primarily use my 6 string for my pedalboard, I went with the EADGCF for a while.
I have also a 6-string from my old Bassist days lying around. A very cheap one. Was just a test.
I bought several basses back then, just shortly bevore my accident, which had me quit as a Bassist.
I´ve set up that one also EADGCF last year, ...ahh wait: i think it is E-A-D-G-hiB-hiE.
I really like that tuning for going thru FX. Just, that Bass is way to haevy for me !
also neckdivy, which i really hate. (but i might invest in a set of headless tuners nevertheless, and ask the hangman to come by with his Bass-guillotine, later this year )
i had also my 5ers set up to hiE ( A-D-G-hiB-hiE),
and from all my playing thru FX, -thru my modular , and thru my PC plugin FX setup - was i definitly under the opinion that these higher strings work way better with quasi all these FX. I never felt that the hiE would be to high in pitch. (too thin from its feel, yes)
A reason i´m buying more basses, i want different tunings.
The B-string is just not working with most of my FX ! its quasi pointless
While i even can have a A-D-G-hiB-hiE strung Bass, sound *very* low with good pitch shifters.
so, in short, point is: the good FX work better with higher strings,
and many of the interesting FX sport a pitchshifter on board anyway.